058 Identification of novel gene classifiers to non-invasively diagnose non-melanoma skin cancer

Non-melanoma skin cancers (NMSC) are the most common types of cancer and include both basal cell carcinoma (BCC) squamous (SCC). NMSC primarily form on sun exposed including head, face, neck, arms, hands. BCC accounts for >75% cases; however, SCC is more aggressive may occur in other locations as well. Combined, responsible >15,000 deaths each year US alone, which exceed due to melanoma. Current diagnosis relies an in-depth visual assessment lesion question followed by a surgical biopsy histopathologic review. This analysis investigated whether non-invasive collection tissue with ‘smart stickers’ subsequent genomic could properly classify NMSC. Adhesive collections kits were used collect lesional from 58 patients BCC, 41 SCC, 42 non-cancerous diseases. Whole transcriptomic was conducted sample differentially expressed genes determined comparing and/or disease (other) using multiple comparisons. Eighteen significantly (fold change >1.5; p<0.1) increased compared diseases while 14 p<0.1). Further identified 12 that These results require further investigation but suggest “smart sticker” enabled sampling provide opportunity identify earlier without need biopsy.